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BackgroundMetformin is the most common oral hypoglycemic used and associated with certain abnormalities. The objective was to evaluate and define the occurrence and bases of vitamin B12 deficiency amongst patients on Metformin for diabetes mellitus type.

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Vitamin B12 is an essential micronutrient required for optimal hemopoetic, neuro-cognitive and cardiovascular function. Biochemical and clinical vitamin B12 deficiency has been demonstrated to be highly prevalent among patients with type 1 and type 2 diabetes mellitus.

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Overview. Vitamin B12 is an essential vitamin found in foods such as meat, fish, and dairy. It can also be made in a lab and is often taken with other B vitamins. Vitamin B12 is required for the.

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People with vitamin B12 deficiency can have neurological symptoms and/or damage without anemia (lack of red blood cells). General physical symptoms of vitamin B12 deficiency can include: Feeling very tired or weak. Experiencing nausea, vomiting or diarrhea. Not feeling as hungry as usual. Weight loss.

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B 12 (also known as cobalamin) is essential for keeping your brain and nerves healthy and for making DNA and red blood cells. B 12 also helps lower levels of homocysteine, an amino acid linked (in high levels) to dementia, heart disease, stroke, and osteoporosis. We typically get B 12 through diet. Rich sources include beef, liver, clams.

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Both diabetes and vitamin B12 deficiency can independently lead to neuropathy. In diabetes, extended periods of high blood sugar levels can cause nerve damage. Vitamin B12 is necessary for healthy.

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B-12 deficiency can also lead to peripheral neuropathy with symptoms that may include numbness, weakness, pain, and paresthesia (a burning or itchy sensation of the skin). It's usually felt on.

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1,000 to 2,000 times as much vitamin B12 as you'd typically eat in a day, so the of vitamin B12 deficiency can take several years to appear. If you have a vitamin B12 deficiency, you may feel tired or weak. These are symptoms of megaloblastic anemia, which is a hallmark of vitamin B12 deficiency. You might also have pale skin, heart.

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Metformin is a drug commonly used to treat type 2 diabetes and other related conditions. People who take metformin may be at risk for a vitamin B12 deficiency. One study showed that 22% of people taking this drug had vitamin B12 levels that were too low. A multivitamin may have helped some people prevent or reverse a deficiency.

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Vitamin B 12, also known as cobalamin, is a water-soluble vitamin involved in metabolism. It is one of eight B vitamins.It is required by animals, which use it as a cofactor in DNA synthesis, and in both fatty acid and amino acid metabolism. It is important in the normal functioning of the nervous system via its role in the synthesis of myelin, and in the circulatory system in the maturation.

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Vitamin C and E supplements won't ward off diabetes and diabetes complications. Until the research shows a clear benefit, it's best to pass on these. The jury's still out on vitamin D. There is an association between higher concentrations of vitamin D in the blood during childhood and a lower risk of type 1 diabetes.

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Vitamin B12 (cobalamin) is a water-soluble vitamin that is derived from animal products such as red meat, dairy, and eggs. Intrinsic factor is a glycoprotein that is produced by parietal cells in the stomach and necessary for the absorption of B12 in the terminal ileum. Once absorbed, B12 is used as a cofactor for enzymes that are involved in the synthesis of DNA, fatty acids, and myelin. As a.